Česká Genetická Banka

Research networks around the world are cataloguing DNA mutations, chemical changes to DNA-associated proteins, and expression of RNA transcripts and proteins in thousands of human tumours.
In a series of 16 papers1, one of which is published on page 333 of this issue (Kandoth et al.)2, The Cancer Genome Atlas (TCGA) Research Network presents comparisons of such data across as many as 12 tumour types.
The publications join other pan-cancer efforts in revealing commonalities between all cancer types, shared molecular abnormalities in tumours that superficially seem distinct, and mutations that are confined to specific tumours.
The findings will guide the development of prognostic, diagnostic and therapeutic strategies. (...)"

"Cellular reprogramming to a stem-cell state has now been achieved in tissues of genetically engineered mice. This work signals a future for regenerative medicine in which tissue fates might be manipulated in living organisms. (...)"