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NATURE: 14. 3. 2013

NATURE: 14. 3. 2013

NATURE: Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

"Although haematopoietic stem cells (HSCs) are commonly assumed to reside within a specialized microenvironment, or niche1, most published experimental manipulations of the HSC niche have affected the function of diverse restricted progenitors. This raises the fundamental question of whether HSCs1 and restricted progenitors2, 3 reside within distinct, specialized niches or whether they share a common niche. Here we assess the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maintenance."

http://www.nature.com/nature/journal/v495/n7440/full/nature11885.html

 

NATURE: CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

"Haematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals generated by stromal cells regulate their self-renewal, proliferation and trafficking. Endosteal osteoblasts1, 2 and perivascular stromal cells including endothelial cells3, CXCL12-abundant reticular cells4, 5, leptin-receptor-positive stromal cells6, and nestin–green fluorescent protein (GFP)-positive mesenchymal progenitors7 have all been implicated in HSC maintenance. However, it is unclear whether specific haematopoietic progenitor cell (HPC) subsets reside in distinct niches defined by the surrounding stromal cells and the regulatory molecules they produce. (...)"

http://www.nature.com/nature/journal/v495/n7440/full/nature11926.html

 

NATURE: Patterns of population epigenomic diversity

"Natural epigenetic variation provides a source for the generation of phenotypic diversity, but to understand its contribution to such diversity, its interaction with genetic variation requires further investigation. Here we report population-wide DNA sequencing of genomes, transcriptomes and methylomes of wild Arabidopsis thaliana accessions. (...)"

http://www.nature.com/nature/journal/v495/n7440/full/nature11968.html

 

NATURE: Stem cells: Anatomy of an ovarian cancer

"Whether ovarian cancer originates in the ovary or the surrounding tissues is a focus of debate. Work in mice now shows that stem cells that replenish the ovarian surface epithelium can be the initiators of this cancer."

http://www.nature.com/nature/journal/v495/n7440/full/nature11962.html

 

NATURE: Ageing gene linked to diabetes

"A gene called SIRT1 is associated with age-related diseases and longevity in some model systems, but it seems that a mutation in this gene may also cause type 1 diabetes. This form of diabetes is a result of the immune system destroying insulin-secreting cells in the pancreas.(...)"

http://www.nature.com/nature/journal/v495/n7440/full/495145c.html

 

SCIENCE: Subset of CD4 Cells May Hold Key to Reaching HIV Cure

"New findings about how a subset of CD4+ white blood cells invaded by HIV may control the course of the disease promise to have a profound impact on the field. These "central memory cells" might even help explain a case announced at the 20th Conference on Retroviruses and Opportunistic Infections that grabbed international headlines: a child had been cured of an HIV infection."

http://www.sciencemag.org/content/339/6125/1262.summary